Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

2



Systemic Juvenile Idiopathic Arthritis – New Aspects of Clinical Features, Diagnostic Tools and Treatment Strategies

Elke Lainka, Johannes Peter Haas, Gerd Horneff, Elisabeth Weißbarth-Riedel, Tim Niehues, Helmut Wittkowski, Ulrich Neudorf.

Abstract
Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease (AID) of unknown etiology related to abnormalities in the innate immune system. The pathogenesis of SJIA differs from all other forms of JIA, which are supposed to be autoimmune diseases. It does not show any association with HLA genes or autoantibodies. Specific autoimmune reactions of the adaptive immune system as in oligo- or polyarticular juvenile idiopathic arthritis (JIA) are not observed in most SJIA cases. In contrast, the major role in the pathogenesis has been ascribed to proinflammatory cytokines interleukin-1 and interleukin-6. Specific inhibition of these two cytokines represents a novel therapeutic approach to the disease which is expected to improve long term prognosis.
Aims: This overview describes our current understanding of clinical features and pathophysiology, as well as the state of the art in diagnostic procedures and treatment options for SJIA.

Key words: Juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis, autoinflammatory disease, biomarkers, biological agents



Share this Article


Advertisement
Journal of Complementary Medicine Research

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons