Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access


J. Vet. Adv.,. 2012; 2(11): 544-551

Central Neuropeptide W has Anorexigenic effect of in Rats

Shousha S., Mohammad M. and Naso T..

Neuropeptide W (NPW) is produced in neurons located in hypothalamus, brain stem, and antral G cells and its receptors are present in the hypothalamus, in particular in the paraventricular nucleus (PVN). There are two forms of the peptide, designated as neuropeptide W-23 (NPW23) and neuropeptide W-30 (NPW30). Neuropeptide W is an endogenous ligand for G protein-coupled receptor, GPR7- and GPR8-receptors (R), which in humans are expressed in the hypothalamus and probably involved in the regulation of energy homeostasis and neuroendocrine axes. We conducted this study to investigate the effects of NPW on feeding intake and energy expenditure in Wistar rats. Systemic (icv) injection of both forms of neuropeptide to ad-libitum feeding Wistar rats decreased dark feeding and fasting-induced feeding. One week of systemic treatment with NPW decreased feeding intake and weight gain during the treatment period. On the other hand, systemic treatment with anti-neuropeptide W antibody increased feeding intake. Moreover, systemic treatment with neuropeptide W raised body temperature and consequently thermogenesis. These results strongly suggest that neuropeptide W may plays an important central role in the feeding intake and energy balance regulation in mammals.

Key words: NPW, feeding intake, heat production, body temperature

Share this Article

American Journal of Physiology, Biochemistry and Pharmacology


ScopeMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons