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Prodrome schizophrenia: Current developments and problems

Murat Emül, M. Müfit Uğur.

Abstract
The term prodrome is used to inform that an event will happen. In prodrome schizophrenia, the person is considered to be symptomatic
and will subsequently develop schizophrenia. It is clear that there is a need to diagnose schizophrenia before its onset as is the case in
cancer screening. Increased duration of untreated psychosis is believed to have harmful consequences. However, there are
questions regarding prodrome schizophrenia such as: do people have similar features in prodrome phase who will eventually develop
schizophrenia or will everyone in prodromal phase develop schizophrenia? Some inventories were developed to screen this
phase. Ultra high risk schizophrenia is formed by the most sensitive and predictive tests. Forty percent of prodrome people who share the
features of the ultra high risk group are found to develop schizophrenia. Recently, the terms of vulnerability for schizophrenia,
schizotaxia, schizotypy have begun to be rediscussed to simplify the identiŞcation of prodrome schizophrenia. The motivation behind the
quest to identify prodrome schizophrenia diagnose is to prevent the individual from the possible toxic effects of schizophrenia to the brain,
to reduce the duration of untreated psychosis and to inşuence the prognose positively via atypical antipsychotics with less adverse
effects. Thus, early pharmacological, behavioral interventions and environmental arrangements for people in the prodrome phase are
on the agenda. Considering the false positive diagnoses, there is need to discuss issues as stigmatization, pharmacological treatment to undiagnosed patients, possible stres facing the individual and his family and related ethical subjects.

Key words: Schizophrenia, prodrome, schizotaxia, high risk



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