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PAFMJ. 2018; 68(1): 13-17


PROTHROMBIN G20210A GENE MUTATION IN PREGNANT FEMALES WITH THROMBOTIC OBSTETRIC COMPLICATIONS

Maha Anis Alam, Mohammad Ayyub, Saqib Qayyum Ahmad, Nosheen Ali.

Abstract
Objective: To determine the frequency of prothrombin G20210A gene mutation in pregnant females with adverse
thrombotic obstetric complication and to compare it with prothrombin G20210A gene’s frequency in control
population.
Study Design: Case control study.
Place and Duration of Study: Department of Haematology, Army Medical College Rawalpindi and Military
Hospital Rawalpindi, from Nov 2013 to Oct 2014.
Material and Methods: Sixty pregnant females were included in the study; 30 were cases with adverse thrombotic
obstetric complication, while 30 were controls. Detailed history was obtained and 3 ml blood in EDTA tube was
collected. DNA was extracted from whole blood and through RT-PCR, presence of prothrombin G20210A gene
mutation was looked for in patients and controls. Data was analyzed using SPSS 21.
Results: A total of 60 women-30 cases with thrombotic obstetric complications as ‘cases’ and 30 as ‘controls’- were
included in the study. Mean age of ‘cases’ was 28.70 ± 4.23 years while that of ‘controls’ was 27.33 ± 4.49 years.
There was no statistically significant difference among the two groups (p=0.54). In case group only one of 30
(3.3%) patients had heterozygous F2 G20210A mutation while 29 (96.7%) patients had wild type allele. In control
group, all the 30 (100%) subjects had wild type allele. The odds of finding the mutation in cases was 1:29 i.e. 0.03
as compared to zero in the control group. The difference was statistically insignificant (p= 0.5).
Conclusion: Our study shows that the frequency of F2 G20210A gene mutation in pregnant females having
adverse thrombotic obstetric complications was not significantly different from its frequency in control
population.

Key words: Prothrombin G20210A gene mutation, Pregnant females, Thrombotic obstetric complications.



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