Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access


Comparison of cardiac inşuences of antipsychotic drugs in patients with schizophrenia

Erhan Kurt, Bilbaşar Akman, Gazi Alataş, Sinan Dağdelen, Timuçin Oral.

Objective: Antipsychotic drugs may cause serious cardiovascular side-effects, including prolonged QT interval, eventually leading to torsades de pointes and sudden death. In this study, the differential effects of antipsychotic drugs on ECG parameters, particularly on QTc, is investigated.

Method: Sixty-nine patients with schizophrenia diagnosed according to DSM-IV diagnostic criteria who were drug-free for at least one month were randomized to participate in this study. The electrocardiogram of patients were performed at the beginning and two months later, and assessed by two independent cardiologists.

Results: In this study, differential effects of antipsychotics (clozapine, olanzapine, risperidone, quetiapine, sulpride, haloperidol) indicated that clozapine has caused a statistically signiŞcant change on heart rate (p

Key words: Schizophrenia, antipsychotics, electrocardiographic changes, QTc

Share this Article

Journal of Molecular Pathophysiology


ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons