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Comparison of the schizotypal features of unaffected First degree relatives of schizophrenic patients with that of healthy control subjects: a preliminary study

Murat Emül, Mihriban Dalkıran, Şenol Turan, Ruhi Yavuz, Alaattin Duran, Müfit Uğur.

Objective: The aim of this study was to compare the schizotypal features of the unaffected Şrst degree relatives of schizophrenic patients with healthy controls.

Methods: The sample was consisted of the relatives of schizophrenic patients, who did not meet any psychiatric diagnostic criteria according to DSM-IV TR and healthy people who and whom Şrstdegree relatives did not have any psychiatric disorder. Subjects were requested to Şll out the Schizotypal Personality Questionnaire.

Results: Odd belief and unusual perceptual experience scores were signiŞcantly higher in healthy group. First-degree relatives of schizophrenia patients had signiŞcantly higher no close friends subscale scores than healthy controls (3.2 versus 2.2). The cognitive perceptual factor score was signiŞcantly higher in healthy control group (8.8 versus 5). With respect to disorganized schizotypy, there
was no signiŞcant difference between groups. The positive schizotypy was signiŞcantly higher in controls (12.2 versus 7.2) whereas negative schizotypy was comparable between groups.

Conclusion: Our study supports the view that the disorganization dimension does not show a familial or a genetic association for schizophrenia. Higher scores in no-close friend sub-dimension which is related to negative symptoms of schizophrenia might be related to familial and genetic features of schizophrenia.

Key words: Disorganization, positive schizotypy, Şrst degree relatives, schizophrenia

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American Journal of Research in Medical Sciences


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