Although most patients with panic disorder readily respond to serotonin reuptake inhibitors, some patients are treatment resistant to standard pharmacological treatments. Switching to another antidepressant, drug combination and augmentation strategies were
suggested to overcome the treatment resistance. There were few case reports in the literature adressing the usage of atypical antipsychotics in the treatment of resistant panic disorder patients. In the most of the cases, olanzapine were added to selective serotonin
reuptake inhibitors. There is no report on augmentation therapy with quetiapine in patients with panic disorder. In this report we presented a patient with panic disorder and agoraphobia who responded well to quetiapine added to ongoing paroxetine treatment.
Panic disorder, atypical antipsychotics, treatment,