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The efficacy of donepezil in two cases with alcohol induced Korsakoff?s Syndrome

Zerrin Binbay, Hasan Mırsal, Ö. Ayhan Kalyoncu, Özkan Pektaş, Yasin Genç, Nasibe Ünsalan, Mansur Beyazyürek.

According to DSM-IV, amnestic disorder, known as ?Alcohol Induced
Persisting Amnestic Disorder? and classically known as ?Wernicke
Encephalopathy? or ?Korsakoff?s Syndrome? is an important clinical
condition because of the poor nutrition most commonly associated
with chronic alcohol abuse. Donepezil, a primarily peripheric and
central acetyl cholinesterase inhibitor, increases acetylcholine
concentration in cholinergic synapses and can improve symptoms of
amnesia. In this article, we present two cases with ?Alcohol Induced
Persisting Amnestic Disorder? and depressive disorder treated by
donepezil, who have shown improvement in cognitive functions. The
patients were followed up with the Hamilton Depression Rating Scale
(HDRS), and Mini Mental State Examination (MMSE) and clinical
observation. In both of the cases, donepezil was added to the antidepressant
drug treatment and improvement in cognitive function
was noted together with improvement in depressive symptoms. In the
first case standard MMSE score increased by 18 points to 26; in the
second case by 16 points to 28. Large-scale prospective, doubleblind,
placebo controlled studies are needed to confirm the efficacy of
donepezil in Alcohol Induced Persisting Amnestic Disorder.

Key words: Korsakoff?s Syndrome, donepezil, amnestic disorder, thiamine deficiency, alcohol dependence

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Journal of Molecular Pathophysiology


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