Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

3



The efficacy of donepezil in two cases with alcohol induced Korsakoff?s Syndrome

Zerrin Binbay, Hasan Mırsal, Ö. Ayhan Kalyoncu, Özkan Pektaş, Yasin Genç, Nasibe Ünsalan, Mansur Beyazyürek.

Abstract
According to DSM-IV, amnestic disorder, known as ?Alcohol Induced
Persisting Amnestic Disorder? and classically known as ?Wernicke
Encephalopathy? or ?Korsakoff?s Syndrome? is an important clinical
condition because of the poor nutrition most commonly associated
with chronic alcohol abuse. Donepezil, a primarily peripheric and
central acetyl cholinesterase inhibitor, increases acetylcholine
concentration in cholinergic synapses and can improve symptoms of
amnesia. In this article, we present two cases with ?Alcohol Induced
Persisting Amnestic Disorder? and depressive disorder treated by
donepezil, who have shown improvement in cognitive functions. The
patients were followed up with the Hamilton Depression Rating Scale
(HDRS), and Mini Mental State Examination (MMSE) and clinical
observation. In both of the cases, donepezil was added to the antidepressant
drug treatment and improvement in cognitive function
was noted together with improvement in depressive symptoms. In the
first case standard MMSE score increased by 18 points to 26; in the
second case by 16 points to 28. Large-scale prospective, doubleblind,
placebo controlled studies are needed to confirm the efficacy of
donepezil in Alcohol Induced Persisting Amnestic Disorder.

Key words: Korsakoff?s Syndrome, donepezil, amnestic disorder, thiamine deficiency, alcohol dependence



Share this Article


Advertisement
Journal of Molecular Pathophysiology

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons