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The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder

Mehmet Yumru, Esen Savaş, H. Serdar Gergerlioğlu, Kemal Başaralı, Aysun Kalenderoğlu, Haluk A. Savaş, Sadık Büyükbaş.

Objective: In this study we aimed to evaluate the relationship between serum
leptin levels, metabolic syndrome and treatment in bipolar patients.

Method: Sixty bipolar I disorder (BD) patients were enrolled; 29 patients were on mood
stabilizer (MS) (lithium, valproic acid, carbamazepin, and lamotrigine)
treatment, 31 patients were on atypical antipsychotics (AA) (risperidone,
quetiapine, and olanzapine) for at least 3 months . Metabolic syndrome (MetS)
was evaluated according to NCEP ATP III (Adult Treatment Protocol of the
National Cholesterol Education Programme) criteria.

Results: 36.7% of the
patients were recognized as MetS. The AA subgroup had significantly more MetS
than MS. Abdominal obesity was significantly correlated with leptin levels in BD.
No significant association was found between MetS and leptin levels in BD.

Discussion: AA taking bipolar patients had higher MetS rates. However, there was
no significant difference among AAs for inducing MetS. Leptin levels were
significantly correlated with abdominal obesity in bipolar patients but seem not
to be associated with MetS.

Key words: Bipolar disorder, metabolic syndrome, leptin, atypical antipsychotics

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American Journal of Diagnostic Imaging


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