Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

3



Naltrexone treatment of self-injurious behavior in autistic patients and two case reports

Gürkan Odabaşıoğlu, Yasin Genç, Özgür Öztürk.

Abstract
Opiates lower the excitation of locus coeruleus via decreasing the firing activity of neurons. It is implicated that dysfunction of opiatergic systems might be mostly responsible for causing social withdrawal behaviour. Increased brain opiatergic activity during neonatal period might decrease social motivation and cause social withdrawal in autistic children. Painful stimulants in post travmatic stress disorder patients increase opiate synthesis in brain and repetetive painful stimulants and şashbacks might reinforce this neurobiological process. Naltrexone, an opiate antagonist, is shown to decrease the şashbacks in patients with posttraumatic stress disorder. The underlying mechanism in which opiate antagonists diminish the self injurious behaviour in autistic children might involve the reduction of opiatergic activity which is increased by painful stimuli and self injurious behaviours. Regarding two cases who are admitted to our inpatient unit, the effects of opiate antagonists as well as their neurobiological mechanisms which lower agression and other potential pharmocological indications were discussed.

Key words: Naltrexone, autism, self injurious behaviour, opiatergic system



Share this Article


Advertisement
Applied Medical Research

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons