Objective: Despite the adequate time and dose of antidepressant treatment, approximately one-third of the patients with major depression do not respond. In previous trials, mirtazapine combination was found to be efficacious in treatment-resistant depression which is non-response to two previous adequate antidepressant drug treatments from different classes. In this present study, it is aimed to assess the efficacy and the tolerability of mirtazapine combination treatment in patients with treatment-resistant major depression by retrospective chart review.
Method: During the period between August 2004 and July 2005, all the charts of the patients with treatment resistant major depressive disorder were selected. For the assessment, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression (CGI) were used. For the assessment of adverse effects, the report of the patients was considered. Forty-three in- or outpatients with major depression who previously received two antidepressants of different groups and did not respond (
Mirtazapine, combination treatment, treatment-resistant depression