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Effect of Pterocarpus marsupium in animal model of high carbohydrate diet-induced metabolic syndrome

Fardan Qadeer Afroz Abidi Fariha Fatima Dilshad Ali Rizvi.

Abstract
Background: Metabolic syndrome (MS) is a group of interconnected disorder linked to obesity, insulin resistance hypertension, and dyslipidemia. It is a risk factor for the development of Type II diabetes and cardiovascular diseases. Thus, there is a need to search for therapeutic options for the treatment of MS.

Aims and Objective: The present study was conducted to evaluate the protective effect of Pterocarpus marsupium (Bijasar) in animal model of high carbohydrate diet-induced MS.

Materials and Methods: Adult male Wistar rats were divided into three groups. All the animals were given 20% sucrose in drinking water ad libitum for 8 weeks for the induction of MS along with the following treatment. Group I (Control): Distilled water; Group II (PM group): Aqueous extract of P. marsupium (200 mg/kg/day); and Group III (Standard treatment): Metformin 100 mg/kg/day + Atorvastatin 10 mg/kg/day. Body weight, abdominal circumference (AC), blood glucose, and serum triglycerides were evaluated at the end of 4 weeks and 8 weeks.

Results: The aqueous extract of P. marsupium at a dose of 200 mg/dl caused a significant reduction (P < 0.05) in the body weight, AC, blood sugar and serum triglyceride levels when compared to the control group. Similar results were seen in the standard treatment group.

Conclusion: PM was effective in the treatment of major components of MS in rat model of high carbohydrate diet‑induced MS.

Key words: Metabolic Syndrome, Pterocarpus Marsupium, Insulin Resistance, Obesity, Heartwood



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