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Aqueous leaf extract of Olea hochstetteri modulates thiopentone- and ketamine-induced anesthesia in rats

Innocent Damudu Peter, Umar Kyari Sandabe, James Yazah Adamu.

Abstract
Objective: Traditionally, olive (Olea hochstetteri) leaves are used as hypotensive, antinociceptive, hypnotic, hypoglycemic and antipyretic agents. However, its influence on anesthetic effect of thiopentone and ketamine has not yet been clarified.
Methods: All experiments were carried out on adult Wistar rats. Graded concentrations (100, 200, 400 and 800 mg/kg) of the aqueous leaf extracts of Olea hochstetteri were administered to one group of rats immediately following thiopentone sodium administration and another group immediately following ketamine hydrochloride administration intraperitoneally. The time for the anesthetic effect was recorded using the righting reflex.
Results: There was significant increase in the sleeping time of rats in both thiopentone- and ketamine-induced anesthesia following the administration of the Olea hochstetteri leaf extract.
Conclusion: The present results suggest that aqueous leaf extract of Olea hochstetteri extends thiopentone- and ketamine-induced anesthesia. This is of particular importance to the anesthesiologists so that peri- and post-operative safety measures are implemented with the routine use of phytotherapy.

Key words: Anesthetic modulation; Olea hochstetteri; Phytotherapy



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