Background: Ischemic heart disease is a leading cause of death throughout the world. Indians are more prone to premature coronary artery disease. About 20% patients with CAD have no identifiable risk factors. Thus the importance of homocysteine as a risk factor for CAD in Indian patients needs to be recognized. Objective: The present study was designed to find out association between the plasma homocysteine and traditional risk factors in young acute myocardial infarction patients. Materials And Methods: The study included 50 male patients of less than 40 years old, who were fulfilling the WHO criteria for acute myocardial Infarction presenting within 48 hours. Plasma homocysteine levels were studied in addition to the traditional risk factors. RESULTS: The mean age of the patients was 34.1 ±4.2years. The mean homocysteine level was 23.58 ±6.2 Î¼mol/L. The prevalence of hyperhomocysteinemia was 70% in the study subjects. Plasma homocysteine levels were significantly increased in patients with smoking. (pâ‰¤0.001),alcoholism(pâ‰¤0.003) and dyslipidemia(pâ‰¤0.006) . Elevation of homocysteine levels in patients with Diabetes mellitus, Hypertension and family history of CAD (coronary artery disease) was not significant. Conclusion: Our results showed that homocysteine levels are elevated in young patients with AMI. In the present study significantly higher level of homocysteine was found in smokers, patients with alcoholism and dyslipidemia. However, there was no significant elevation was found in Diabetes mellitus, Hypertension and family history of CAD. Plasma homocysteine has emerged as a significant independent risk factor for young MI patients. Therefore, plasma homocysteine should be evaluated in all young patients with myocardial infarction especially in the absence of traditional risk factors. [Suthar H et al NJIRM 2013; 4(1) : 72-77]
Acute myocardial infarction, young adults, homocysteine, conventional risk factors.