Objective: Childhood disintegrative disorder is a relatively uncommon condition that is characterized by marked regression in several areas of functioning after at least two years of apperantly normal developmant.A case of disintegrative disorder in a 16 year-old girl was discussed in the light of the clinical literature in this article. Method: Literature on childhood disintegrative in the past 15 years were reviewed. Results: Progressive cortical atrophy which is identified by brain MRI, no secondary sex characteristics, echolalia before total loss speech, and progressive deterioration of psychological functions were observed in this case. Conclusion: Although there are similiarities between autism and disintegrative disorder which has progressive deterioration of cognitive and motor abilities and cortical atrophy suggested that it is a neurodegenerative disorder; autism disorder which has no progressive deterioration and cortical atrophy considered that it is a neurodevelopmental disorder.
Childhood Disintegrative Disorder, Autistic Disorder, Pervasive Developmental Disorder