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JNBS. 2012; 1(2): 17-29


THE EFFECTS OF LITHIUM AND CARBAMAZEPINE TO CARDIAC FUNCTIONS

E. Erdal ERŞAN, Süleyman ASLAN, Orhan DOĞAN.

Abstract
Objective: The aim of this study that determining and comparing the effects of lithium and carbamazepine on
cardiac functions node to find out the appearing cases widespread and determining the required conditions related to cardiology.
Methods: Forty-eight cases were taken to this study. These cases have been using lithium or carbamazepine for
at least one year. They do not have any known heart or systematic or neurologic disorders and on remission in
the case of primer disease. These people also do not use alcohol or any other substances. Among these 48
cases, 31 of them have been using lithium and rest (17) of them carbamazepine. This number contains all the
events that applied to the psychiatric department and provides the required conditions in which we work. After
taking the cases approvals, a sociodemographic form was filled out. In the lithium group, after looking at the
serum lithium levels, in orders of electrocardiography, exercise test a 24 hour Holter registration, carotis sinus
massage, atropine test and intrinsic heart rate test were done.
Results: In the cases that use lithium, 9.7% of t negative has been determined. In the exercise test it has been
found out that 35.5% in the lithium group and 17.6% in the carbamazepine group have chronotropic incomepetence.
Asistoly was not determined with carotis sinus massage in both of these groups. The atropine test on
lithium users was considered abnormal with a ratio of 22.6%, and no abnormality was determined in the carbamazepine
group. Between the two groups, especially worse in the lithium group, it has been found out that the
difference was meaningful because of the minimum and average heart rate. In the exercise test maximum heart
rate and chronotropic incompetence, in holter registration, maximum heart rate, supraventricular ectopy, ventricular
ectopy and intrinsic heart rate had been researched and it was seen that there were no statistically differences
between these two groups.
Conclusion: As a result, it can be said that lithium has a more evident effect on sinus node compared with
carbamazepine.
Key words: lithium, carbamazepine, cardiac functions, bipolar disorder

Key words: lithium, carbamazepine, cardiac functions, bipolar disorder



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