Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

1

Natl J Integr Res Med. 2013; 4(2): 5-10


Comparison Of Two Doses Of Oral Clonidine As A Premedicant For Attenuation Of Pressor Response To Laryngoscopy

Dr. Shah Hetal D**, Dr. Shah Megha*.

Abstract
Background: The present study compared oral clonidine 0.3mg with 0.2 mg to attenuate hemodynamic response to laryngoscopy and intubation and also to evaluate the optimal dose of oral clonidine as premedication. Methods: A prospective, randomized, double blind trial performed on 40 patients of ASA Grade I & II, scheduled for planned ENT surgeries under general anaesthesia. Patients were divided into 2 groups depending on oral clonidine dose given 90 mins prior to induction. Group A received 0.3 mg while group B received 0.2 mg clonidine. Heart rate, SBP, DBP, MAP were monitored at various time intervals e.g. before premedication, before induction, at laryngoscopy, intubation, immediately after intubation and post intubation for 30 minutes. Patients were anesthetized with sodium thiopentone (2.5%) 5-7 mg/kg followed by suxamethonium 2 mg/kg i.v. Results: We observed a significant decrease in mean HR,SBP,DBP,MAP in both the groups (clonidine 0.2 and 0.3mg ) as compared to baseline and preinduction level. Tablet Clonidine 0.3 mg proved to be significantly effective in checking the rise in SBP. A highly significant (p < 0.01) fall in DBP was observed in Group A at 1, 3, 15, 30 mins post intubation as compared to Group B. At 3 min, 15 min and 30 min interval, highly significant (p

Key words: clonidine, premedication, pressure response, laryngoscopy



Share this Article


Advertisement
Journal of Environmental and Occupational Science

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons