Patients suffering from chronic renal insufficiency, who need to be treated with dialysis, are generally heavily impaired due to the regular, long lasting treatments. One way to escape this si- tuation is renal transplantation. However, patients with multiple blood transfusions or previous preg- nancies are often sensitized, leading to a poor prog- nosis of the immunologic acceptance of the donor organ. To enable even these patients to be trans- planted with an improved prognosis, besides immunosupression, the treatment with procedures of immunoadsorption is a promising therapy option. Four highly sensitized patients were treat- ed with immunoadsorption (2 men/2 women, range of age: 22-49 years). All patients were previously treated with renal transplantation. We noticed sig- nificant reduction in Panel Reactive Antibodies (PRA) from 68% (50%-80%) before the beginning of treatment to 2% (0%-5%) after the end of them. In spite of limited experience, immunoadsorption can safely and effectively remove anti-HLA in End-Stage Renal Failure patients.
Immunoadsorption, kidney trans- plantation, renal insufficiency