Investigation of Hypoglycemic Effect of Ceiba Pentandra Root Bark Extract in Normal and Alloxan Induced Diabetic Albino RatsSaif-ur-Rehman, Saghir A. Jafri, Ishtiaq Ahmed, Abdul Shakoor,
Hafiz M.N. Iqbal, Bilal Munir Ahmad, Imran Tipu.
The present work was designed to investigate the hypoglycemic effect of Ceiba pentandra root bark extract in normal and alloxan induced diabetic rats. To investigate the effect of Ceiba pentandra 40 albino rats were included in this study divided into four groups of ten rats in each group. Group A and B rats were normal while diabetes was induced in group C and D rats by intraperitoneal injection of alloxan dissolved in 1mL of distilled water at a dose of 125mg/kg body weight. The Ceiba pentandra root bark extract was given orally at a dose of 150mg/kg of body weight. Data was taken after seven days of administration of alloxan. After the induction of diabetes the group B and D rats were treated with Ceiba pentandra root bark extract at a dose of 150mg/kg of body weight. Group A and C rats were not treated with Ceiba pentandra root bark extract. The blood samples from all the rats were collected from coccygial vein on 1st day, then on 21st and 42nd day respectively. All the samples were analyzed for blood glucose level by using enzymatic kits. The blood glucose level of treated groups of rats showed significant reduction after 7 weeks of treatment with Ceiba pentandra root bark extract. By statistical analysis of results it was found that Ceiba pentandra root bark extract has hypoglycemic effect in normal and alloxan induced diabetic rats.
Albino rats, alloxan, Ceiba pentandra, hypoglycemic effect
American Journal of Physiology, Biochemistry and Pharmacology
SUBMIT YOUR ARTICLE NOW