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Med Arch. 2013; 67(3): 202-204


Does Oxybutynin Hydrochloride Cause Arrhythmia in Children with Bladder Dysfunction?

Ilhan Ciftci, Derya Arslan, Harun Peru, Derya Cimen, Bulent Oran, Metin Gunduz.

Abstract
Aim: Pediatric surgeons frequently encounter children presenting with voiding dysfunction symptoms, including urgency, frequency, and incontinence. Antimuscarinic agents (Oxybutynin) are the main drugs used to treat patients with overactive bladder (OAB) syndrome, defined as urgency, with or without urgency incontinence, usually with increased daytime frequency and nocturia. Increased QT dispersion is known to be the cause of ventricular arrhythmia in various systemic diseases and leads to increased mortality and morbidity. Method: This study represents a subset of a complete data set, considering only those children aged admitted to the Pediatric Surgery and Pediatric Nephrology Clinics during the period January 2011 to July 2012. Result: In this study, we have determined that the QT interval changes significantly depending on the use of oxybutynin. The QT changes increased cardiac arrhythmia in children. Conclusion: For this reason, children using such drugs should be closely monitored for cardiac arrhythmia.

Key words: cholinergic antagonists; oxybutynin; urinary incontinence; overactive bladder; children; QT interval.



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