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Med J Bakirkoy. 2011; 7(4): 130-135

Advanced glycation end–products and advanced oxidation protein products in patients with insulin dependent diabetes mellitus and first degree relatives

Alev Kural, Aysun Toker, Hatice Seval, Yasemin Döventaş, Filiz Basınoğlu, Macit Koldaş, Zuhal A. Sağlam.

Objective: There is no comprehensive information on the relationship of diabetic complications and the duration and severity of hyperglycemia. In this study, we aimed to determine oxidative stress markers in patients with insulin dependent diabetes mellitus and their first degree relatives.
Materials and Methods: 45 patients with Type I diabetes mellitus and 24 relatives of these patients were included in our study. Plasma advanced oxide protein products (AOPP), serum glucose, urea, creatinine, cholesterol, triglyceride, HDL-cholesterol, total protein, albumin, advanced glication end products (AGE) and HbA1c measurements were measured by appropriate methods.
Results: AOPP and AGE levels were found to be slightly elevated in diabetic patients with or without complications compared to the levels of first degree relatives however the difference was not statistically significant.
Conclusion: When we had compared the parameteres in two groups (insulin dependent diabetic patients and non diabetic parents or siblings), we found weak relation between glucose and AGE (r= 0.25, p

Key words: Type I Diabetes Mellitus, advanced glycation end products, advanced oxidation protein products, diabetes complications, first degree relatives

İnsüline bağımlı diyabetik hastalarda ve 1. Derece akrabalarında ileri glikozillenme ve ileri okside protein ürünleri

Amaç: Hiperglisemi düzeyi ve süresi ile diyabet komplikasyonlarının ilişkisi hakkında genel literatür bilgilerimiz tatmin edici düzeyde değildir. Bu çalışmamızda, oksidatif stres belirteçlerinin insüline bağımlı diyabetik hastalarda ve akrabalarında seviyelerinin belirlenmesi amaçlandı.
Gereç ve Yöntem: Çalışmamıza, 45 tip 1 diyabetes mellitus (DM) hastası ve bu hastaların 24 yakını dahil edildi. Plazma ileri okside protein ürünleri (AOPP), serum glikoz, üre, kreatinin, total kolesterol, trigliserid, HDL-kolesterol, total protein, albumin, ileri glikozillenme ürünü (AGE), ve HbA1c düzeyi ölçümleri uygun metolarla ölçüldü.
Bulgular: AOPP ve AGE düzeyleri komplikasyonlu veya komplikasyonsuz diyabetik hastalarda, diyabetik olmayan birinci derece akrabalara göre hafif yüksek bulundu; ancak istatistiksel olarak anlamlı değildi (p

Anahtar Kelimeler: Tip I Diyabetes Mellitus, İleri glikasyon son ürünleri, AOPP, Diyabet komplikasyonları, 1.derece akrabalar

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