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Med J Bakirkoy. 2010; 6(4): 137-141


Botulinum toxin type A application in dystonia

Murat Çabalar, Vildan Yayla, Tülay Yetkin.

Abstract
Objective: Botulinum toxin (BTX) causes muscle paralysis by blocking acetylcholine secretion at the neuromuscular junctions. In this study, results of BTX applications in our neurology department were described. Analysis of dystonia patients and the duration of BTX efficacy were investigated.
Material and Methods: Fiftyseven dystonia patients, who admitted to our outpatient clinics between July 2007-August 2009, were injected by Botulinum type A. In this treatment, dental injector for the neck and extremity muscles, insulin injectors for the facial muscles were used. Statistically, Student t-test was applied. Results were considered significant at the level of p0,05).
Conclusion: Botulinum A toxin treatment is safe and effective for all dystonia types, especially HFS and BFS.

Key words: Movement disorders, dystonia, Botulinum toxin A



Distonide botulinum toksini tip A uygulaması

Özet
Amaç: Botulinum toksini (BTX), sinir terminallerinde asetil kolin salınımını inhibe ederek kas paralizisi oluşturur. Bu çalışmada kliniğimizde BTX uygulamalarının sonuçları değerlendirildi. Distoni hastalarının dağılımı ve BTX’den yararlanma süreleri incelendi.
Gereç ve Yöntem: Temmuz 2007-Ağustos 2009 arasında Nöroloji Kliniği’ne başvuran 57 distoni hastasına Botulinum A toksini uygulandı. Uygulamada boyun ve ekstremite kasları için dental, yüz kasları için insülin enjektörü seçildi. İstatistiksel olarak Student t testi kullanıldı, anlamlılık p0,05).
Sonuç: Botulinum A toksini, özellikle HFS ve BFS olmak üzere, tüm distonilerin tedavisinde etkili ve güvenli bir yöntemdir.

Anahtar Kelimeler: Hareket bozuklukları, distoni, Botulinum toksin A



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