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The efficiency of preoperative tumor marker levels for definition of malignancy and spread in adnexial masses

İbrahim Ömeroğlu, Osman Aşıcıoğlu, Gürsel Otlu, Osman Temizkan, Sibel Özsoy, Ramazan Adan, Berhan Besimoğlu Aşıcıoğlu, Ali Şahap Odacılar.

Abstract
Objective: The place of CA 12-5, CA 15-3, CA 19-9, CEA, AFP and ß HCG, which are tumor markers used in screening over carcinoma, in differentiating benign or malign adnexial masses, and the correlation of these markers with the pathological diagnosis and stage of the tumor were evaluated.
Material and Method: Two hundred seventy seven patients who were operated with the diagnosis of adnexial mass at Şişli Etfal Training and Research Hospital Gynecology and Obstetrics Clinic between January 2006 and August 2011 were analyzed retrospectively.
Results: Efficiency levels of tumor markers as diagnostic tests were studied by ROC curve method. The area under the ROC curve was calculated as 0.872 unit frames for CA 12-5, 0.739 for CA 15-3, 0.522 for CA 19-9, 0.614 for CEA, 0.433 for AFP and 0.635 for ß HCG.
Conclusion: Markers other than CA 12-5 and CA 15-3 could not found significant in the statistical evaluation for the discrimination of benign and malignant. The discriminative power of each tests were analyzed by statistical ROC curve method. At the analysis, CA 12-5 was found as the most valuable marker. While the discriminative value of CA 15-3 was found acceptable, other tests were found invaluable. Only CA 12-5 had showed a correlation with the tumor stage.

Key words: CA 12-5, malign over tumor, tumor stage



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