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Med Bull Sisli Etfal Hosp. 2012; 46(3): 148-152


Long term renal replacement and plasmapheresis therapy in case of hemolytic uremic syndrome: intensive care unit experience

Ozan Gökuç, Hacer Şebnem Türk, Tolga Totoz, Oya Ünsal, Gül Şumlu Özçelik, Sibel Oba.

Abstract
Hemolytic uremic syndrome (HUS) is a clinical situation which is characterized by hemolytic anemia, thrombocytopenia and acute renal failure. This syndrome is one of the most common causes of acute renal failure in infants and children. There is two types of HUS. Typical HUS is the most frequent form of HUS in children, occurs due to Shigatoxin and %90 presents after diarrhea and upper airway infection. Atypical HUS is a primary disease due to a disorder in complement alternative pathway regulation and known as non Shigatoxin-HUS. 5-10% of HUS in children is atypical HUS and 20% of these cases have extra renal manifestations. Rates of deterioration to the end-stage renal failure and mortality are high at first episode. Normalizing hipertansion, appropriate fluid and electrolyte therapy, early dialysis and nutritional support decreases the mortality. Nowadays, intensive plasmatherapy is the first line treatment. By our case; we aimed to discuss the intensive support treatment, longterm renal replacement treatment and plasmatherapy in HUS.

Key words: Hemolytic Uremic Syndrome, plasmatherapy, intensive care



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