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Hemolytic and DNA nicking studies of anti-cancer peptide

Jagatheesh Kaliaperumal, Kowsalya Rangasamy, Parvathavarthini P,Pavankumar Padarthi, Elangovan Namasivayam.

Abstract
Background: In recent years studying of in vitro toxicity encompass their possess significance to proceed any compound to further pharmaceutical procedure. In this we taken peptide which is supposed to be bind with DNA to produce anti-cancer possessions so it requires studying for its genotoxic possessions.

Aims & Objective: To study Hemolytic and DNA nicking of anti-cancer peptide.

Materials and Methods: Simple agarose gel was used to electrophoresis to determine the DNA nicking property and hemolytic assay also performed to ensure the safety of the peptide in biological system.

Results: It was found that peptide is being safe even at elevated concentration 40 ng which cannot be achieved in biological distribution and the hemolytic assay shows the IC50 value 25.24 μg/ml which is also an awfully higher concentration in in vivo terms.

Conclusion: It is concluded the peptide have safe use in biological system.

Key words: Peptide; Electrophoresis; DNA Nicking; Haemolytic Assay



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