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Gaziantep Med J. 2011; 17(1): 8-10


Clinical Outcomes of Children Admitted with Admission Diagnosis of Pandemic Influenza

Hamza Yazgan, Zerrin Yazgan, Mehmet Demirdöven, Ahmet Ruhi Toraman, Muzaffer Çakmak, Ahmet Gürel.

Abstract
This study was designed to review the risk factors, clinical status and clinical outcomes of patients with an admission diagnosis of pandemic influenza A. Out of 503 patients seen at our hospital’s outpatient Pediatric Unit for flu symptoms between November and December 2009, 42 were admitted. These 42 patients’ risk factors, symptoms, reasons for admission, clinical treatment course and clinical outcomes were analyzed retrospectively. H1N1 was diagnosed using the real-time Reverse Transcriptase-Polymerase Chain Reaction Method (RT-PCR) in nasopharyngeal swabs. Of the 42 patients included in the study, 19 were male (45.2%) and 23 were female (54.8%). The mean age was 8.8 years (patient ages range from six months to 17 years of age). 28 patients were PCR positive (66.6%) and 14 were PCR negative (33.4%). Investigation of risk factors revealed 12 patients with asthma (28.5%), two with cerebral palsy (%4.76), up until one years old children two (%4.76), and one Down Syndrome patient with congenital heart disease (%4.76). No risk factors were identified for 25 patients (59.5%). Admission diagnoses included 15 patients with acute bronchiolitis (35.7%), 12 with acute pharyngitis and general poor health (28.6%), eight with pneumonia (19%), three with acute sinusitis (7%), two with acute gastroenteritis (4.7%) and two with febrile seizures (4.7%). All patients were given oseltamir at admission. The average length of stay was five days (ranging from 2-8 days). One patient required mechanical ventilator and intensive care services. There were no mortalities in the study group. In the event of a new pandemic influenza, patients in the risk groups identified may experience lower risk of mortality if provided with close monitorization and early treatment of potential secondary infections.

Key words: Influenza A; H1N1; mortality; risk factor; clinical results



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