Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

1

Gaziantep Med J. 2011; 17(1): 29-32


mRNA Expressions of SOCS3 Gene in Meningitis Patients

Serdar Öztuzcu, Ahmet Arslan, Ercan Sivaslı, Mustafa Namıduru, Yusuf Ziya İğci, Esma Özkara, Mehri İğci, Zeynep Eşlik, Recep Bayraktar, Ecir Ali Çakmak, Mehmet Yavuz Coşkun.

Abstract
Meningitis is an inflammatory disease caused by microorganisms and viruses with various clinical symptoms, which damages the brain tissue and membranes, and which induces biochemical and cellular changes in cerebrospinal fluid (CSF). Meningitis is an infectious disease with higher rates of mortality and morbidity. The possibility of death or permanent damage to patient is considerable, mortality rate is one in ten patients and permanent damages like deafness or various brain damages are one in seven patients. Experimental animal meningitis revealed that the leukocytes infiltrated in CSF due to bacterial dissemination contributed to damage progression in brain tissue, increased brain edema and intracranial pressure. The association between gene expression of SOCS3 which is effective in repressing the JAK/STAT signal transduction pathway and meningitis disease were investigated in this study. Gene expression levels of SOCS3 in leukocytes leaked to CSF were investigated by using real-time PCR method in this study. As a result of our study, there was no difference in blood SOCS3 gene expression levels between meningitis patients and healthy controls (p>0.05). Additionally, there was no meaningful difference between SOC3 gene expression of blood and CSF samples in meningitis patients (p>0.05). Our data suggests that further molecular studies are needed and important in meningitis disease diagnosis and treatment, and in the other genes responsible for repressing of inflammatory development.

Key words: Meningitis; Real Time PCR; SOCS3



Share this Article


Advertisement
American Journal of Preventive Medicine and Public Health

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons