Every year breast cancer afflicting females claims the lives of thousands of women all over the globe. The aim of the study was to assign relative significance of 5´Adenosine deaminase [5´ADA] and 5´ Nucleotidase [5´NT] as a marker for diagnosis of Carcinoma Breast and to evaluate correlation between levels of these enzymes and stages of malignancy, presence of metastasis and response to treatment. 50 diagnosed patients of carcinoma of breast before any treatment were grouped as untreated group and compared with normal controls (50). Untreated patients followed up after 3 months of treatment were estimated for above enzymes. These serum levels were compared with that of untreated patients. Serum 5´ADA & 5´NT levels were increased significantly in cases as compared to controls. There was progressive increase in the concentration of enzymes from Stage I to Stage IV in untreated patients. The decrease in serum 5´ADA level was also parallel to the stage in treated group. Reduction in level of 5´NT was significant in Stage I and II while nonsignificant in Stage III & Stage IV. When mean reduction of enzyme levels after treatment was compared in patients with secondaries & without secondaries it was more appreciable for 5´ADA than 5´NT. Thus from our study 5´ ADA may serve as diagnostic tumour marker and has important role in predicting progression and regression of disease in course of treatment. Serum5´Nucleotidase has the only diagnostic significance and raised value may predict the extent if disease.
Carcinoma breast, Serum 5´Adenosine deaminase, 5´Nucleotidase.