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Sertoli-Leydig cell tumor (arrhenoblastoma) in adolescent age group

Swarnalata Samal, Amogh Chimote, Rohit Juneja, Madhuprita Agrawal.

Arrhenoblastoma, also known as Sertoli-Leydig cell tumors or androblastomas, are very rare neoplasm of the ovaries, resulting in the overproduction of the male hormone testosterone. This is a rare tumour which accounts for less than 0.5% of all ovarian tumours. These tumours are found in women of all age groups, but are most common in young women. Presence of an ovarian tumour plus hormonal disturbances suggests a Sertoli-Leydig cell tumour. Patients present with a recent history of progressive masculinisation. Masculinisation is preceded by anovulation, oligomenorrhoea, amenorrhoea and defeminisation. Arrhenoblastomas are generally unilateral benign tumour; do not normally spread beyond the ovary, occurring in reproductive age. This work summarizes the morphological and immunohistochemical characteristics of this tumour in a 15-year old girl with clinical signs of virilisation. A 14 year old female admitted with abdominal distension, change in voice, male pattern balding and clitoromegaly in the dept. of Ob/Gy A.V.B.R.H. (Acharya Vinoba Bhave Rural Hospital) Sawangi, Wardha. Investigations included Sonography C.T scan, ascetic tap, Serum testosterone was done. She was managed by exploratory Laparotomy and follow up was advised. On follow up her serum testosterone levels and sonography was done. Here we are representing the case.

Key words: Sertoli-Leydig cell tumor, Ferriman-Galleway scoring, Hirsutism, Virilisation

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Journal of Interdisciplinary Histopathology


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