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Hematopoietic Stem Cell Transplantation and History

Atila Tanyeli, Gülcan Aykut, Ahmet Onur Demirel, Tuğba Akçaoğlu.

Abstract
Attemps to employ marrow stem cell for therapeutic purpose began in 1940’s. Marrow transplantation might be of use not only in irradiation protection, but also with therapeutic aim to marrow aplasia, leukemia and other diseases. The use and defining tissue antigens in humans were crucial to the improving of transplantation. The administration of methotrexate for GVHD improved the long term survival. Conditioning regimens for myeloablation designed according to diseases. Cord blood and peripheral blood stem cells were used for transplantion after 1980’s. Cord blood and bone marrow stem cell banks established to find HLA matched donor.

Key words: Stem cell, bone marrow transplantation, history



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