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BMMR. 2014; 17(2): 63-66


Posterior Interosseous Nerve Lesion Due to Thrombosis in a Newborn: A Case Report

Muzaffer Durmus, Selim Turkkan, Harun Yasin Tuzun, Alparslan Bayram Carli, Arsen Arsenishvili, Yalcın Kulahci, Mustafa Kurklu.

Abstract
Thrombosis in the newborn is a severe condition that may cause mortality and/or serious morbidity. Although the most frequently cause of the newborn thrombosis is catheters, spontaneous cases may also be seen. Arterial thrombosis is very seldom and it is responsible for the half of the thrombotic conditions in the newborn. Genetic prothrombotic risk factors influence the formation of thrombosis.
In our case, skin necrosis due to thrombosis following circulation insufficiency in the dorsolateral region of the left forearm was detected. Plasma homocysteine levels and other prothrombotic components were elevated. Soft tissue debridement was applied and it was followed up for secondary healing. In the follow up period, lesion in the posterior interosseous branch of the radial nerve was determined. It was considered that this lesion was either due to the thrombosis or the surgical debridement.
Newborns that have increased levels of plasma homocysteine levels and medical history of congenital arterial thrombosis should be investigated for MTHFR gene C677T and A1298C polymorphism with genetic analyses.
In this study, we reported a premature newborn with thrombosis in the left forearm and lesion in the posterior interosseous branch of the radial nerve associated with methylene tetrahidrofolate reductase (MTHFR) gene A1298C polymorphism heterozygotism.

Key words: Newborn, Metyhlenetetrahydrofolate Reductase, Heterozygote, Thrombosis



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