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IJCRR. 2013; 5(19): 110-120


INTERACTION OF EMBLICA OFFICINALIS WITH FAMOTIDINE AND PANTOPRAZOLE IN PYLORUS LIGATION INDUCED GASTRIC ULCERS IN RATS

Kanani Neeta J., Bhave Amol L., Bhatt Jagatkumar D..

Abstract
Background: Emblica officinalis (EO) is widely used in Ayurveda for various ailments on account of itís medicinal properties of which it has stood test of time for its use in peptic ulcer. However currently there is no report in literature about combining it with allopathic anti-ulcer agents used in peptic ulcer.
Objective: To study interaction of EO with antiulcer agents, famotidine and pantoprazole in pylorus ligation induced gastric ulcers in rats.
Materials and Methods: Gastric ulcers in rats were induced by method of pyloric ligation as described by Shay et al. Effects of different doses of famotidine, pantoprazole and EO on volume, pH, acidity, and ulcer index were observed. Also effects of EO in combination with famotidine or pantoprazole were studied for the same.
Results: Famotidine (4mg/kg i.p.), pantoprazole (4mg/kg i.p.) and EO (100mg/kg p.o.) produced significant anti-ulcer effects in terms of reduction in acidity and ulcer index. Famotidine (1mg/kg i.p.), pantoprazole (1mg/kg i.p.) and EO (50mg/kg p.o.) did not alter the above parameters significantly.Simultaneous administration of (50mg/kg) and famotidine (1mg/kg) showed significant anti-ulcer effects which were apparent from reduction in acidity and ulcer index without causing any change in pH value. Similarly, pantoprazole (1mg/kg) combined with EO (50mg/kg) showed significant anti-ulcer effects on similar lines but with significant rise in volume of gastric secretion.
Conclusion: EO produced pantoprazole with EO may be recommended for management of peptic ulcer with an advantage of minimizing side effects and drug interactions of former drugs while getting benefits from EO like its antioxidant property.

Key words: Combined Therapy, Emblica officinalis, famotidine, pantoprazole, pyloric ligation



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