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Role of Caffeic acid phenethyl ester on 1-nitropyrene and/or gamma irradiation induced oxidative damage in rats

Amira Abd El- Raof Mohammad, Ola Ali Gharib, Nour El-Din Amin, Yasser Mohammad Moustafa.

Abstract
AIM: The study was aimed to investigate the role of cumulative intraperitoneally (I.P) doses (60 Ámol/ Kg) of caffeic acid phenethyl ester (CAPE) on oxidative damage induced in liver and lung of irradiated rats (6 Gy fractionated dose of gamma rays) and/ or cumulative oral doses (100 mg/kg for six consecutive days) of 1- nitropyrene (1-NP).
METHOD: Ninety six male albino rats were divided into three experiments [Irradiated (IRR), 1-NP and IRR+ 1-NP experiments] each has four groups of eight rats: normal control, CAPE, oxidative stress factors (IRR and/ or 1- NP), and CAPE + oxidative stress factors. CAPE was injected along with radiation and/ or 1- NP administration. Serum alkaline phospatase (ALP), gamma-glutamyl transferase (╬│-GT), alanine transaminase (ALT), aspertate transaminase (AST) and lactate dehydroginase (LDH) concentrations were estimated as well as liver and lung malonaldehyde (MDA) and reduced glutathione (GSH).
RESULTS: Serum activity of liver enzymes, LDH and tissues MDA levels increased accompanied with a decrease of GSH content in oxidative stress groups as compared to control groups. CAPE administration ameliorates the disturbance in serum enzyme activities and tissue oxidative stress markers.
CONCLUSION: So one can concluded that CAPE may ameliorate the exposure to environmental pollutants induced oxidative changes in both liver and lung by strengthening the antioxidant defense system via reducing reactive oxygen species and increasing antioxidant enzyme activities.

Key words: Caffeic acid phenethyle ester, 1- nitropyrene, radiation exposure, oxidative damage.



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