Objective: to assess plasma levels of urea nitrogen, creatinine and albumin in Sudanese patients with Type 2 Diabetes Mellitus in comparison with healthy Sudanese volunteers.
Methods: A total of 100 patients with type 2 diabetes mellitus and 50 age and gender matched healthy controls were included in this study. Blood specimens were collected from both groups, and Biosystem spectrophotometeric methods were used for measurement of the plasma levels of urea nitrogen, creatinine, albumin, fasting glucose and glycated hemoglobin. Statistical Package for Social Science (SPSS version 16) computer software was used for data analysis.
Results: urea and creatinine were significantly elevated with significant positive correlation with each of body mass indexes, duration of diabetes, and glycated hemoglobin. Albumin was significantly reduced with significant negative correlation with duration of diabetes, body mass indexes, and glycated hemoglobin. There was significant strong positive correlation between fasting blood glucose and glycated hemoglobin.
Conclusion: plasma levels of urea, creatinine, and albumin can be used as prognostic markers and predictors of renal failure in diabetic patients especially those with complications such as hypertension and ischemic heart disease.
Type 2 Diabetes Mellitus; Urea Nitrogen; Creatinine; Albumin