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JARMS. 2013; 5(3): 243-246


A Study of Chronic Dust Exposure induced Oxidative Stress and its effect on Lung Functions in Street Cleaners

*Shadab Mohammad, Agrawal D. K., Aslam Mohammad, Islam Najmul, Ahmad Zuber.

Abstract
Aim: Street cleaners are exposed to different types of dusts, Bio-aerosols and fumes etc. which produce Oxidative Stress. The pro-oxidant molecules like Reactive Oxygen Species(ROS) and Reactive Nitrogen Species(RNS) promote contractile dysfunction resulting in muscle weakness and fatigue. So we carried out this study to see the effect of dusts ,fumes in oxidative stress production and its effect on Lung functions in these occupationally exposed persons(Street cleaners working for more than last five years). Material and Methods: This Cross Sectional Study was done in Tertiary care Hospital(J.N. Medical college) in Aligarh, U.P. between March 2008 till December 2009 in which study group comprised of 110 Street Cleaners (working for more than five years) and 60 Control subjects. The Pulmonary Functions of these workers were assessed using MIR (Medical International Lab) Spiro Lab II Spirometer in sitting position after taking valid written consent. Malondialdehyde (MDA) is produced after the action of Reactive Oxygen Species(ROS) on lipids in the membranes of the cells specially contracting muscle cells and its Serum levels was used as an indirect measure of oxidative stress in these Street Cleaners and its level was compared to Control subjects. Results: There was statistically significant decrease in Peak Expiratory Flow Rate (PEFR), Forced Expiratory Volume in first second( FEV1), and Forced Expiratory Flow at 25%-75% of volume as percentage of Vital Capacity (FEF 25%-75%). Also the study showed statistically significant increased levels of Serum MDA in these Street Cleaners as compared to control subjects(p value

Key words: Street Cleaners ,Oxidative Stress, Lung Functions, MIR Spiro Lab II Spirometer  



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