Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

1

Gulhane Med J. 2007; 49(4): 222-225


The effects of long-term carbamazepine, phenobarbital and valproic acid therapy on thyroid and parathyroid functions

Ercan Uğur, Cihan Meral, Ferhan Karademir, Selami Süleymanoğlu, Seçil Aydınöz, İsmail Göçmen.

Abstract
Carbamazepine, phenobarbital and valproic acid are used as antiepileptic drugs in many types of epilepsy. Although these antiepileptic drugs are well tolerated, it is known that they have some side effects on endocrine system. In this study, we investigated the effects of carbamazepin, phenobarbital and valproic acid treatment on thyroid and parathyroid functions of 120 cases (58 female and 62 male with ages ranging between 5 months to 14 years) followed-up with the diagnosis of epilepsy, and compared these effects with those of a control group. Complete blood count, serum levels of calcium, phosphorus, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, free triiodothyronine, free thyroxine, thyroid stimulating hormone, parathyroid hormone and serum drug concentrations were measured in all cases. Carbamazepin and phenobarbital except for valproic acid significantly decreased free thyroxine levels. Free triiodothyronine and thyroid stimulating hormone levels did not differ significantly between the study and control groups. Parathormone levels significantly increased in the groups of phenobarbital and carbamazepine when compared to the control group. No significant differences were observed among the groups regarding serum calcium and phosphorus levels. We conclude that thyroid and parathyroid functions of patients using carbamazepine and phenobarbital for a long time should be regularly monitored.

Key words: Phenobarbital, carbamazepine, parathyroid, thyroid, valproic acid



Share this Article


Advertisement
American Journal of Diagnostic Imaging

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons