Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

1

Gulhane Med J. 2008; 50(4): 267-272


Proanthocyanidine alleviates lung damage induced by nitrogen mustard

Orhan Yücel 1, Onur Genç 1, Önder Öngürü 2, Ahmet Aydın 3, Mehmet Ali Şahin 4, Adem Güler 4, Turan Karayılanoglu 5, Ahmet Sayal 3, Mehmet Dakak 1.

Abstract
Destructive properties of nitrogen mustard especially on respiratory system make it an effective chemical weapon with lack of an antidote. The aim of this study was to investigate the role of oxidative stress in mustard toxicity and the protective effect of proanthocyanidine. Rats were separated into three groups each containing fifteen rats. The three groups were control group which were exposed to none, nitrogen mustard group administered nitrogen mustard, and the last group administered nitrogen mustard and fed with proanthocyanidine containing diet (nitrogen mustard plus proanthocyanidine group). We demonstrated the harmful effects of nitrogen mustard over oxidative stress, and the therapeutic effects of proanthocyanidine by both histopathologically and biochemically using the oxidative stress parameters such as malondialdehyde, superoxide dismutase, catalase and glutathione peroxidase. Significant histopathologic lung lesions such as alveolar edema and alveolar congestion were observed in the nitrogen mustard group. Those lesions were less severe in the nitrogen mustard plus proanthocyanidine group. Proanthocyanidine treatment decreased malondialdehyde levels, which were initially elevated by nitrogen mustard administration, while superoxide dismutase, catalase and glutathione peroxidase activities remained similar to those of the nitrogen mustard only group. Our results revealed that oxidative stress has played a major role in mustard toxicity, and proanthocyanidine has had a substantial role in decreasing the toxic outcomes.

Key words: Glutathione peroxidase, lung damage, malondialdehyde, nitrogen mustard, proanthocyanidine



Share this Article


Advertisement
Journal of Complementary Medicine Research

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.
Scopemed Buttons