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Vet World. 2011; 4(4): 183-188


Application of Monoclonal Antibodies in Veterinary Parasitology

A. Gupta, A. K. Dixit, Pooja Dixit, Chetana Mahajan.

Abstract
The discovery of hybridoma technology by Kohler and Milstein in 1975, heralded a new era in antibody research. Mouse hybridomas were the first reliable source of monoclonal antibodies. The generation of monoclonal antibodies from species other than rats and mice, has developed slowly over the last 30 years. The advent of antibody engineering and realization of the advantages of non murine antibodies has increased their relevance recently. However, in the area of veterinary parasitology, monoclonal antibodies are just beginning to fulfill the promises inherent in their great specificity for recognizing and selectively binding to antigens. This review describes the recent advances in the application of monoclonal antibodies for immunodiagnosis / prophylaxis and immunotherapy of parasitic diseases.

Key words: Coccidiosis, Fasciolosis, Immunodiagnosis, Immunotherapy, Monoclonal antibody, Vaccine, Parasite, Parasitology, Hybridoma.



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