BACKGROUND: Encephalopathy is a major complication in juvenile diabetes mellitus which cripples the potential physiomorphological growth and development in early childhood. It is very essential to diagnose and initiate the treatment at the earliest to prevent the possible complications. The ancient medical science Ayurveda mentions number of remedies to treat cognitive dysfunctions, the herbal root of Clitoria ternatea plant is one among them.
METHODS: The diabetes was induced in 22 days (post natal) wistar rats by giving intra peritoneal injection of Streptozotocin at a dose of 60 mg/kg body weight (bw). After the confirmation of diabetic state, the treatment with oral administration of alcoholic root extract of Clitoria ternatea at a dose of 100 mg/kg bw was started immediately and continued for one month of duration. At the end of 30 days treatment the animals were sacrified, brain and pancreatic tissue was collected and they were subjected to gross histological studies.
RESULTS: On microscopy the brain tissue was showing homogenous architecture, the hippocampal CA3 region neurons were showing gross viable changes in the cell morphology, and in the pancreatic tissue, there was a reduction in the cell hypertrophy along with relatively less inflammatory changes in the islet cells of Langerhans.
CONCLUSSION: The alcoholic root extract of herb Clitoria ternatea has shown significant gross impact in preventing the possible complications related to brain hippocampal area CA3 and pancreatic tissue in juvenile diabetic rat experimental models. These benefits could be due to interference of number of chemical compounds present in this extract.
Hippocampus, hyperglycemia, juvenile diabetes, piknosis, Streptozotocin