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Antidiarrhoeal activity of Cistus ladaniferus aqueous extract

Mohammed Aziz, Ahmed Karim, Naoual Tab, Hassane Mekhfi, Mohammed Bnouham, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Fouad Atmani.

Abstract
AIM: Cistus ladaniferus L. (Cistaceae) is a plant which is traditionally used for the treatment of intestinal pain and diarrhea in Morocco. The aim of this study is to evaluate antidiarrhoeal activity of aqueous extract of this plant.
METHODS: Aqueous extract of aerial part (stems and leaves) of Cistus ladaniferus was decocted and evaporated to give a crude residue (yield: 18%). It is bioassayed for their antidiarrhoeal effect by the two standard methods of bioassay of the antidiarrheal activity: Castor oil-induced diarrhoea and Gastrointestinal transit test.
RESULTS: The aqueous extract of Cistus ladaniferus L. given orally at the dose 300 and 600 mg/kg, showed significant antidiarrhoeal activity in castor oil induced diarrhoea and reduced the frequency of diarrhoeal episodes in rat. At 600 mg/kg it decreased the propulsion of charcoal meal through the gastrointestinal tract in mice by 30.71%.
COCLUSION: These results suggested that the extract may contain biologically active components that may be useful against diarrhoea, thereby justifying its use in ethnomedical practice.

Key words: Cistus ladaniferus; Antidiarrhoeal activity; Castor oil; Intestinal transit.



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