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Observational study on standardized Salacia root extract in patients with Type-2 Diabetes mellitus

Satyajyoti##Kanjilal Amitabha ##Dey Rajarshi ##Biswas Deepa ##Gandhi Bibhuti #Nath #Bhatt Kamarujjaman ##Mondal Avinash ##Narwaria Chandra #Kant #Katiyar.

Abstract
Objective: Salacia is used by the folklore practitioners of Southern Asia and mentioned in Ayurvedic texts for management of diabetes. The present observational study was conducted on standardized root extract of Salacia oblonga with a primary objective to obtain data on glycemic response and associated symptoms. Methodology: In 100 diabetic patients, S. oblonga extract (240 mg/tab) tablet was given twice daily before meals along with their routine anti-diabetic therapy. In the observational period the patients were followed up at every month participants carried on doing their regular activities and other dietary measures. Results: A trend of reduction in fasting, postprandial blood glucose levels and glycosylated hemoglobin was noted in the subsequent follow up visits with a statistically significant reduction at the end of 3 months compared to baseline. Periodical follow up suggested that there is an improving trend of the quality of life in respect of symptoms of diabetes such as fatigability, weakness, increased appetite, increased thirst, tingling sensation, and increased urinary frequency when compared with baseline value measure in visual analog scale. Conclusion: Standardized S. oblonga extract can be a potential promising therapeutic agent useful for prevention and management of diabetes by controlling the blood sugar level. It may help in improving the symptoms of quality of life in diabetics. It can be safe and effective option for co-administration with other drugs

Key words: Salacia oblonga; Quality of Life; Antidiabetic; Glycated hemoglobin; blood sugar



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